The daughter of Eurytos, the king of Oichalia. Eurytos held an archery contest, to see who would marry Iole. Needing a wife, Heracles traveled to Oichalia and won the contest. Eurytos, however, refused to let his daughter be married to him. He feared another one of Heracles' fits of madness and his grandsons killed.
Later, Heracles returned to Oichalia, to seek his revenge upon Eurytos. He attacked the town, killed Eurytos, and took Iole as his concubine. Deianeira, the wife of Heracles, became jealous of Iole, and accidentally poisoned her husband.